Wednesday, November 16, 2011

Finding drug to boost 'good cholesterol' proves elusive

For 24 years, patients have had a way to lower their "bad cholesterol" with medications.

But doctors are still struggling to find a drug that safely raises "good cholesterol," which carries bad cholesterol out of the blood.

A preliminary study, presented Tuesday at the American Heart Association meeting in Orlando, shows preliminary evidence that a new class of drugs might help.

The drug evacetrapib, part of a class of medications called CETP inhibitors, more than doubled patients' "good" HDL cholesterol, according to an early study of nearly 400 patients. The drug also substantially lowered "bad" LDL cholesterol. This class of drug "raises HDL cholesterol much more than any other drug we have in clinical practice," says the study's lead researcher, Stephen Nicholls of the Cleveland Clinic.

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